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Association of an aurora kinase a (AURKA) gene polymorphism with progression-free survival in patien...

Association of an aurora kinase a (AURKA) gene polymorphism with progression-free survival in patien...

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_1865525812

Association of an aurora kinase a (AURKA) gene polymorphism with progression-free survival in patients with advanced urothelial carcinoma treated with the selective aurora kinase a inhibitor alisertib

About this item

Full title

Association of an aurora kinase a (AURKA) gene polymorphism with progression-free survival in patients with advanced urothelial carcinoma treated with the selective aurora kinase a inhibitor alisertib

Publisher

New York: Springer US

Journal title

Investigational new drugs, 2017-08, Vol.35 (4), p.524-528

Language

English

Formats

Publication information

Publisher

New York: Springer US

More information

Scope and Contents

Contents

Summary
Background and purpose
Salvage therapies for urothelial carcinoma are needed. A single-arm trial in patients with advanced or metastatic urothelial carcinoma refractive to other therapies found that alisertib, a selective inhibitor of aurora kinase A, maintained stable disease in a few cases, despite a low objective response rate. To...

Alternative Titles

Full title

Association of an aurora kinase a (AURKA) gene polymorphism with progression-free survival in patients with advanced urothelial carcinoma treated with the selective aurora kinase a inhibitor alisertib

Identifiers

Primary Identifiers

Record Identifier

TN_cdi_proquest_miscellaneous_1865525812

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_1865525812

Other Identifiers

ISSN

0167-6997

E-ISSN

1573-0646

DOI

10.1007/s10637-017-0440-5

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