Simvastatin Inhibits IL-1β-Induced Apoptosis and Extracellular Matrix Degradation by Suppressing the...
Simvastatin Inhibits IL-1β-Induced Apoptosis and Extracellular Matrix Degradation by Suppressing the NF-kB and MAPK Pathways in Nucleus Pulposus Cells
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Author / Creator
Tu, Ji , Li, Wentian , Zhang, Yukun , Wu, Xinghuo , Song, Yu , Kang, Liang , Liu, Wei , Wang, Kun , Li, Shuai , Hua, Wenbin and Yang, Cao
Publisher
New York: Springer US
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Language
English
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Publisher
New York: Springer US
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Contents
Statins are widely used hypocholesterolemic drugs that block the mevalonate pathway. Some studies have shown that statins may have the potential to inhibit intervertebral disk (IVD) degeneration (IDD). Interleukin (IL)-1β, a catabolic cytokine, is a key regulator of IDD. This study aimed to investigate the mechanism underlying the effect of simvast...
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Full title
Simvastatin Inhibits IL-1β-Induced Apoptosis and Extracellular Matrix Degradation by Suppressing the NF-kB and MAPK Pathways in Nucleus Pulposus Cells
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Record Identifier
TN_cdi_proquest_miscellaneous_1867537432
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_1867537432
Other Identifiers
ISSN
0360-3997
E-ISSN
1573-2576
DOI
10.1007/s10753-017-0516-6
