Detecting DNA cytosine methylation using nanopore sequencing
Detecting DNA cytosine methylation using nanopore sequencing
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New York: Nature Publishing Group US
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Language
English
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New York: Nature Publishing Group US
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A hidden Markov model (HMM)-based tool enables detection of 5-methylcytosine (5-mC) from single-molecule nanopore-sequencing data generated directly from human genomic DNA without chemical treatment.
In nanopore sequencing devices, electrolytic current signals are sensitive to base modifications, such as 5-methylcytosine (5-mC). Here we quantifi...
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Full title
Detecting DNA cytosine methylation using nanopore sequencing
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TN_cdi_proquest_miscellaneous_1870642614
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_1870642614
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ISSN
1548-7091
E-ISSN
1548-7105
DOI
10.1038/nmeth.4184
