Reporter cell lines for detection of pertussis toxin in acellular pertussis vaccines as a functional...
Reporter cell lines for detection of pertussis toxin in acellular pertussis vaccines as a functional animal-free alternative to the in vivo histamine sensitization test
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Publisher
Netherlands: Elsevier Ltd
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English
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Publisher
Netherlands: Elsevier Ltd
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Abstract Detoxified pertussis toxin (pertussis toxoid) is a major antigen in acellular pertussis vaccines. Testing these vaccines on the presence of residual pertussis toxin (PTx) and reversion to toxicity is performed by the regulatory required in vivo Histamine Sensitization test (HIST). Lack of mechanistic understanding of the HIST, technical ha...
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Full title
Reporter cell lines for detection of pertussis toxin in acellular pertussis vaccines as a functional animal-free alternative to the in vivo histamine sensitization test
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TN_cdi_proquest_miscellaneous_1872829223
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_1872829223
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ISSN
0264-410X
E-ISSN
1873-2518
DOI
10.1016/j.vaccine.2017.01.011
