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Discovering Anti-platelet Drug Combinations with an Integrated Model of Activator-Inhibitor Relation...

Discovering Anti-platelet Drug Combinations with an Integrated Model of Activator-Inhibitor Relation...

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_1872833449

Discovering Anti-platelet Drug Combinations with an Integrated Model of Activator-Inhibitor Relationships, Activator-Activator Synergies and Inhibitor-Inhibitor Synergies: e1004119

About this item

Full title

Discovering Anti-platelet Drug Combinations with an Integrated Model of Activator-Inhibitor Relationships, Activator-Activator Synergies and Inhibitor-Inhibitor Synergies: e1004119

Publisher

San Francisco: Public Library of Science

Journal title

PLoS computational biology, 2015-04, Vol.11 (4)

Language

English

Formats

Publication information

Publisher

San Francisco: Public Library of Science

More information

Scope and Contents

Contents

Identifying effective therapeutic drug combinations that modulate complex signaling pathways in platelets is central to the advancement of effective anti-thrombotic therapies. However, there is no systems model of the platelet that predicts responses to different inhibitor combinations. We developed an approach which goes beyond current inhibitor-i...

Alternative Titles

Full title

Discovering Anti-platelet Drug Combinations with an Integrated Model of Activator-Inhibitor Relationships, Activator-Activator Synergies and Inhibitor-Inhibitor Synergies: e1004119

Identifiers

Primary Identifiers

Record Identifier

TN_cdi_proquest_miscellaneous_1872833449

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_1872833449

Other Identifiers

ISSN

1553-734X

E-ISSN

1553-7358

DOI

10.1371/journal.pcbi.1004119

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