Safety and efficacy of natalizumab in patients with acute ischaemic stroke (ACTION): a randomised, p...
Safety and efficacy of natalizumab in patients with acute ischaemic stroke (ACTION): a randomised, placebo-controlled, double-blind phase 2 trial
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Author / Creator
Elkins, Jacob, Dr , Veltkamp, Roland, Prof , Montaner, Joan, Prof , Johnston, S Claiborne, Prof , Singhal, Aneesh B, Prof , Becker, Kyra, Prof , Lansberg, Maarten G, Prof , Tang, Weihua, PhD , Chang, Ih, PhD , Muralidharan, Kumar, MS , Gheuens, Sarah, MD , Mehta, Lahar, MD and Elkind, Mitchell S V, Prof
Publisher
England: Elsevier Ltd
Journal title
Language
English
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Publisher
England: Elsevier Ltd
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Contents
Summary Background In animal models of acute ischaemic stroke, blocking of the leukocyte-endothelium adhesion by antagonism of α4 integrin reduces infarct volumes and improves outcomes. We assessed the effect of one dose of natalizumab, an antibody against the leukocyte adhesion molecule α4 integrin, in patients with acute ischaemic stroke. Methods...
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Full title
Safety and efficacy of natalizumab in patients with acute ischaemic stroke (ACTION): a randomised, placebo-controlled, double-blind phase 2 trial
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Record Identifier
TN_cdi_proquest_miscellaneous_1872845140
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_1872845140
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ISSN
1474-4422
E-ISSN
1474-4465
DOI
10.1016/S1474-4422(16)30357-X
