A Kinase-Regulated Mechanism Controls CFTR Channel Gating by Disrupting Bivalent PDZ Domain Interact...
A Kinase-Regulated Mechanism Controls CFTR Channel Gating by Disrupting Bivalent PDZ Domain Interactions
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Publisher
United States: National Academy of Sciences
Journal title
Language
English
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Publisher
United States: National Academy of Sciences
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Scope and Contents
Contents
Dynamic regulation of ion channels is critical for maintaining fluid balance in epithelial tissues. Cystic fibrosis, a genetic disease characterized by impaired fluid transport in epithelial tissues, is caused by dysfunctional cystic fibrosis transmembrane conductance regulator (CFTR) Cl-channel activity. Recent studies have shown that binding of P...
Alternative Titles
Full title
A Kinase-Regulated Mechanism Controls CFTR Channel Gating by Disrupting Bivalent PDZ Domain Interactions
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Author / Creator
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Record Identifier
TN_cdi_proquest_miscellaneous_18806654
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_18806654
Other Identifiers
ISSN
0027-8424
E-ISSN
1091-6490
DOI
10.1073/pnas.1633250100
