CHIP/Stub1 regulates the Warburg effect by promoting degradation of PKM2 in ovarian carcinoma
CHIP/Stub1 regulates the Warburg effect by promoting degradation of PKM2 in ovarian carcinoma
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Publisher
London: Nature Publishing Group UK
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Language
English
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Publisher
London: Nature Publishing Group UK
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Contents
Tumor cells preferentially adopt aerobic glycolysis for their energy supply, a phenomenon known as the Warburg effect. It remains a matter of debate as to how the Warburg effect is regulated during tumor progression. Here, we show that CHIP (carboxyl terminus of Hsc70-interacting protein), a U-box E3 ligase, suppresses tumor progression in ovarian...
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Full title
CHIP/Stub1 regulates the Warburg effect by promoting degradation of PKM2 in ovarian carcinoma
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TN_cdi_proquest_miscellaneous_1881772517
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_1881772517
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ISSN
0950-9232
E-ISSN
1476-5594
DOI
10.1038/onc.2017.31
