The influences of SLCO1B1 and ABCB1 genotypes on the pharmacokinetics of simvastatin, in relation to...
The influences of SLCO1B1 and ABCB1 genotypes on the pharmacokinetics of simvastatin, in relation to CYP3A4 inhibition
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Publisher
England: Future Medicine Ltd
Journal title
Language
English
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Publisher
England: Future Medicine Ltd
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Scope and Contents
Contents
To investigate the combined effects of SLCO1B1 and ABCB1 genotypes on the pharmacokinetics of simvastatin and its active metabolite simvastatin acid, in relation to CYP3A4 inhibition.
We conducted a single-dose pharmacokinetic study of simvastatin in 26 healthy volunteers screened for their SLCO1B1 c.521T>C and ABCB1 c.1236C>T-2677G>T-3435C>T ge...
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Full title
The influences of SLCO1B1 and ABCB1 genotypes on the pharmacokinetics of simvastatin, in relation to CYP3A4 inhibition
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Record Identifier
TN_cdi_proquest_miscellaneous_1882083481
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_1882083481
Other Identifiers
ISSN
1462-2416
E-ISSN
1744-8042
DOI
10.2217/pgs-2016-0199
