Insulin Regulates the Activity of Forkhead Transcription Factor Hnf-3β/Foxa-2 by Akt-Mediated Phosph...
Insulin Regulates the Activity of Forkhead Transcription Factor Hnf-3β/Foxa-2 by Akt-Mediated Phosphorylation and Nuclear/Cytosolic Localization
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Publisher
National Academy of Sciences
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Language
English
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National Academy of Sciences
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Hepatocyte nuclear factors 3$\alpha,\>\beta$, and γ (Foxa-1, -2, and -3) are transcriptional activators of important metabolic genes in the liver that are suppressed by the actions of insulin. Here, we show that the activation of phosphatidylinositol 3-kinase-Akt by insulin induces Foxa-2 phosphorylation, nuclear exclusion, and inhibition of Foxa-2...
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Full title
Insulin Regulates the Activity of Forkhead Transcription Factor Hnf-3β/Foxa-2 by Akt-Mediated Phosphorylation and Nuclear/Cytosolic Localization
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TN_cdi_proquest_miscellaneous_18830828
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_18830828
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ISSN
0027-8424
E-ISSN
1091-6490
DOI
10.1073/pnas.1931483100
