An Efficient and Rapid Method to Monitor the Oxidative Degradation of Protein Pharmaceuticals: Probi...
An Efficient and Rapid Method to Monitor the Oxidative Degradation of Protein Pharmaceuticals: Probing Tyrosine Oxidation with Fluorogenic Derivatization
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Publisher
New York: Springer US
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Language
English
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Publisher
New York: Springer US
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Purpose
The loss of potency of protein therapeutics can be linked to the oxidation of specific amino acid residues leading to a great variety of oxidative modifications. The comprehensive identification of these oxidative modifications requires high-resolution mass spectrometry analysis, which requires time and expensive resources. Here, we prop...
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Full title
An Efficient and Rapid Method to Monitor the Oxidative Degradation of Protein Pharmaceuticals: Probing Tyrosine Oxidation with Fluorogenic Derivatization
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TN_cdi_proquest_miscellaneous_1889766298
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_1889766298
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ISSN
0724-8741
E-ISSN
1573-904X
DOI
10.1007/s11095-017-2159-6
