From basic apoptosis discoveries to advanced selective BCL-2 family inhibitors
From basic apoptosis discoveries to advanced selective BCL-2 family inhibitors
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Publisher
London: Nature Publishing Group UK
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Language
English
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Publisher
London: Nature Publishing Group UK
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Key Points
Members of the B cell lymphoma 2 (BCL-2) gene family have a key role in regulating programmed cell death by controlling pro-apoptotic and anti-apoptotic intracellular signals.
Augmentation of anti-apoptotic signalling is a hallmark of cancer; inhibition of specific anti-apoptotic BCL-2 proteins represents an important novel therape...
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Full title
From basic apoptosis discoveries to advanced selective BCL-2 family inhibitors
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TN_cdi_proquest_miscellaneous_1897374134
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_1897374134
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ISSN
1474-1776
E-ISSN
1474-1784
DOI
10.1038/nrd.2016.253
