Predictive compound accumulation rules yield a broad-spectrum antibiotic
Predictive compound accumulation rules yield a broad-spectrum antibiotic
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Publisher
London: Nature Publishing Group UK
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Language
English
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Publisher
London: Nature Publishing Group UK
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Contents
Most small molecules are unable to rapidly traverse the outer membrane of Gram-negative bacteria and accumulate inside these cells, making the discovery of much-needed drugs against these pathogens challenging. Current understanding of the physicochemical properties that dictate small-molecule accumulation in Gram-negative bacteria is largely based...
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Full title
Predictive compound accumulation rules yield a broad-spectrum antibiotic
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TN_cdi_proquest_miscellaneous_1897803973
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_1897803973
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ISSN
0028-0836
E-ISSN
1476-4687
DOI
10.1038/nature22308
