Highly efficient RNA-guided base editing in mouse embryos
Highly efficient RNA-guided base editing in mouse embryos
About this item
Full title
Highly efficient RNA-guided base editing in mouse embryos
Author / Creator
Publisher
New York: Springer New York
Journal title
Nature biotechnology, 2017-05, Vol.35 (5), p.435-437
Language
English
Formats
Publication information
Publisher
New York: Springer New York
Subjects
More information
Scope and Contents
Contents
Mice with targeted point mutations are generated efficiently using Cas9–cytidine deaminase fusions.
Base editors (BEs) composed of a cytidine deaminase fused to CRISPR–Cas9 convert cytidine to uridine, leading to single-base-pair substitutions in eukaryotic cells. We delivered BE mRNA or ribonucleoproteins targeting the
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Alternative Titles
Full title
Highly efficient RNA-guided base editing in mouse embryos
Authors, Artists and Contributors
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_proquest_miscellaneous_1901762526
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_1901762526
Other Identifiers
ISSN
1087-0156
E-ISSN
1546-1696
DOI
10.1038/nbt.3816
