A mitochondrial UPR-mediated metabolic checkpoint regulates hematopoietic stem cell aging
A mitochondrial UPR-mediated metabolic checkpoint regulates hematopoietic stem cell aging
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Publisher
Washington: American Association for the Advancement of Science
Journal title
Language
English
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Publisher
Washington: American Association for the Advancement of Science
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Scope and Contents
Contents
Deterioration of adult stem cells accounts for much of aging-associated compromised tissue maintenance. How stem cells maintain metabolic homeostasis remains elusive. Here, we identified a regulatory branch of the mitochondrial unfolded protein response (UPRmt), which is mediated by the interplay of SIRT7 and NRF1 and is coupled to cellular energy...
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Full title
A mitochondrial UPR-mediated metabolic checkpoint regulates hematopoietic stem cell aging
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TN_cdi_proquest_miscellaneous_1904206325
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_1904206325
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ISSN
0036-8075
E-ISSN
1095-9203
DOI
10.1126/science.aaa2361
