Sperm calcineurin inhibition prevents mouse fertility with implications for male contraceptive
Sperm calcineurin inhibition prevents mouse fertility with implications for male contraceptive
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Publisher
United States: American Association for the Advancement of Science
Journal title
Language
English
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Publisher
United States: American Association for the Advancement of Science
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Contents
Calcineurin inhibitors, such as cyclosporine A and FK506, are used as immunosuppressant drugs, but their adverse effects on male reproductive function remain unclear. The testis expresses somatic calcineurin and a sperm-specific isoform that contains a catalytic subunit (PPP3CC) and a regulatory subunit (PPP3R2). We demonstrate herein that male mic...
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Full title
Sperm calcineurin inhibition prevents mouse fertility with implications for male contraceptive
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Record Identifier
TN_cdi_proquest_miscellaneous_1904223576
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_1904223576
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ISSN
0036-8075
E-ISSN
1095-9203
DOI
10.1126/science.aad0836
