Cytosolic detection of the bacterial metabolite HBP activates TIFA-dependent innate immunity
Cytosolic detection of the bacterial metabolite HBP activates TIFA-dependent innate immunity
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Publisher
Washington: American Association for the Advancement of Science
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Language
English
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Publisher
Washington: American Association for the Advancement of Science
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Contents
Host recognition of pathogen-associated molecular patterns (PAMPs) initiates an innate immune response that is critical for pathogen elimination and engagement of adaptive immunity. Here we show that mammalian cells can detect and respond to the bacterial-derived monosaccharide heptose-1,7-bisphosphate (HBP). A metabolic intermediate in lipopolysac...
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Full title
Cytosolic detection of the bacterial metabolite HBP activates TIFA-dependent innate immunity
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TN_cdi_proquest_miscellaneous_1904235030
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_1904235030
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ISSN
0036-8075
E-ISSN
1095-9203
DOI
10.1126/science.aaa4921
