Cold-induced conversion of cholesterol to bile acids in mice shapes the gut microbiome and promotes...
Cold-induced conversion of cholesterol to bile acids in mice shapes the gut microbiome and promotes adaptive thermogenesis
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Author / Creator
Worthmann, Anna , John, Clara , Rühlemann, Malte C , Baguhl, Miriam , Heinsen, Femke-Anouska , Schaltenberg, Nicola , Heine, Markus , Schlein, Christian , Evangelakos, Ioannis , Mineo, Chieko , Fischer, Markus , Dandri, Maura , Kremoser, Claus , Scheja, Ludger , Franke, Andre , Shaul, Philip W and Heeren, Joerg
Publisher
New York: Nature Publishing Group US
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Language
English
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Publisher
New York: Nature Publishing Group US
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Contents
During cold stimulation, cholesterol is converted to bile acids in an alternative pathway. The bile acids then alter the microbiota, which in turn promotes more heat generation.
Adaptive thermogenesis is an energy-demanding process that is mediated by cold-activated beige and brown adipocytes, and it entails increased uptake of carbohydrates, as...
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Full title
Cold-induced conversion of cholesterol to bile acids in mice shapes the gut microbiome and promotes adaptive thermogenesis
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TN_cdi_proquest_miscellaneous_1908797131
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_1908797131
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ISSN
1078-8956
E-ISSN
1546-170X
DOI
10.1038/nm.4357
