O-GlcNAcylation of fumarase maintains tumour growth under glucose deficiency
O-GlcNAcylation of fumarase maintains tumour growth under glucose deficiency
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Author / Creator
Wang, Ting , Yu, Qiujing , Li, Jingjie , Hu, Bin , Zhao, Qin , Ma, Chunmin , Huang, Wenhua , Zhuo, Lingang , Fang, Houqin , Liao, Lujian , Eugene Chin, Y. and Jiang, Yuhui
Publisher
London: Nature Publishing Group UK
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English
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Publisher
London: Nature Publishing Group UK
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Chromatin-associated fumarase (FH) affects histone methylation via its metabolic activity. However, whether this effect is involved in gene transcription remains to be clarified. In this study, we show that under glucose deprivation conditions, AMPK phosphorylates FH at Ser75, which in turn forms a complex with ATF2 and participates in promoter act...
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Full title
O-GlcNAcylation of fumarase maintains tumour growth under glucose deficiency
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TN_cdi_proquest_miscellaneous_1911200615
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_1911200615
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ISSN
1465-7392
E-ISSN
1476-4679
DOI
10.1038/ncb3562
