Plk1 regulates contraction of postmitotic smooth muscle cells and is required for vascular homeostas...
Plk1 regulates contraction of postmitotic smooth muscle cells and is required for vascular homeostasis
About this item
Full title
Author / Creator
de Cárcer, Guillermo , Wachowicz, Paulina , Martínez-Martínez, Sara , Oller, Jorge , Méndez-Barbero, Nerea , Escobar, Beatriz , González-Loyola, Alejandra , Takaki, Tohru , El Bakkali, Aicha , Cámara, Juan A , Jiménez-Borreguero, Luis J , Bustelo, Xosé R , Cañamero, Marta , Mulero, Francisca , de los Ángeles Sevilla, María , Montero, María Jose , Redondo, Juan Miguel and Malumbres, Marcos
Publisher
New York: Nature Publishing Group US
Journal title
Language
English
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Publication information
Publisher
New York: Nature Publishing Group US
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More information
Scope and Contents
Contents
The kinase Plk1 has been studied primarily as a mitotic regulator in dividing cells, but de Cárcer
et al
. find that Plk1 deficiency or inhibition in mice causes nonmitotic defects in the vasculature, including aortic aneurysm and rupture, as well as defective vascular smooth muscle contractility. These results recommend a note of caution in...
Alternative Titles
Full title
Plk1 regulates contraction of postmitotic smooth muscle cells and is required for vascular homeostasis
Authors, Artists and Contributors
Author / Creator
Wachowicz, Paulina
Martínez-Martínez, Sara
Oller, Jorge
Méndez-Barbero, Nerea
Escobar, Beatriz
González-Loyola, Alejandra
Takaki, Tohru
El Bakkali, Aicha
Cámara, Juan A
Jiménez-Borreguero, Luis J
Bustelo, Xosé R
Cañamero, Marta
Mulero, Francisca
de los Ángeles Sevilla, María
Montero, María Jose
Redondo, Juan Miguel
Malumbres, Marcos
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_proquest_miscellaneous_1917666106
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_1917666106
Other Identifiers
ISSN
1078-8956
E-ISSN
1546-170X
DOI
10.1038/nm.4364
