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Reduced TRPC6 mRNA levels in the blood cells of patients with Alzheimer’s disease and mild cognitive...

Reduced TRPC6 mRNA levels in the blood cells of patients with Alzheimer’s disease and mild cognitive...

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_1917962714

Reduced TRPC6 mRNA levels in the blood cells of patients with Alzheimer’s disease and mild cognitive impairment

About this item

Full title

Reduced TRPC6 mRNA levels in the blood cells of patients with Alzheimer’s disease and mild cognitive impairment

Publisher

London: Nature Publishing Group UK

Journal title

Molecular psychiatry, 2018-03, Vol.23 (3), p.767-776

Language

English

Formats

Publication information

Publisher

London: Nature Publishing Group UK

More information

Scope and Contents

Contents

Transient receptor potential canonical 6 (TRPC6) inhibits β-amyloid (Aβ) production. Hyperforin, the TRPC6 agonist, reduces Aβ levels and improves cognitive performance in Alzheimer’s disease (AD) models. However, it’s unknown whether TRPC6 expression is changed in AD patients. In this case–control study, we measured TRPC6 expression levels in the...

Alternative Titles

Full title

Reduced TRPC6 mRNA levels in the blood cells of patients with Alzheimer’s disease and mild cognitive impairment

Identifiers

Primary Identifiers

Record Identifier

TN_cdi_proquest_miscellaneous_1917962714

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_1917962714

Other Identifiers

ISSN

1359-4184

E-ISSN

1476-5578

DOI

10.1038/mp.2017.136

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