Molecular characterization of a t(1;3)(p36;q21) in a patient with MDS. MEL1 is widely expressed in n...
Molecular characterization of a t(1;3)(p36;q21) in a patient with MDS. MEL1 is widely expressed in normal tissues, including bone marrow, and it is not overexpressed in the t(1;3) cells
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Publisher
London: Nature Publishing Group UK
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Language
English
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Publisher
London: Nature Publishing Group UK
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Patients with myeloid malignancies and either the 3q21q26 syndrome or t(1;3)(p36;q21) have been reported to share similar clinicopathological features and a common molecular mechanism for leukemogenesis. Overexpression of
MDS1/EVI1
(3q26) or
MEL1/PRDM16
(1p36), both members of the PR-domain family, has been directly implicated in the ma...
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Full title
Molecular characterization of a t(1;3)(p36;q21) in a patient with MDS. MEL1 is widely expressed in normal tissues, including bone marrow, and it is not overexpressed in the t(1;3) cells
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TN_cdi_proquest_miscellaneous_19258320
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_19258320
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ISSN
0950-9232
E-ISSN
1476-5594
DOI
10.1038/sj.onc.1206923
