Structural basis for removal of adenine mispaired with 8-oxoguanine by MutY adenine DNA glycosylase
Structural basis for removal of adenine mispaired with 8-oxoguanine by MutY adenine DNA glycosylase
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Publisher
London: Nature Publishing Group UK
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Language
English
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Publisher
London: Nature Publishing Group UK
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Contents
The genomes of aerobic organisms suffer chronic oxidation of guanine to the genotoxic product 8-oxoguanine (oxoG)
1
. Replicative DNA polymerases misread oxoG residues and insert adenine instead of cytosine opposite the oxidized base. Both bases in the resulting A·oxoG mispair are mutagenic lesions, and both must undergo base-specific replace...
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Full title
Structural basis for removal of adenine mispaired with 8-oxoguanine by MutY adenine DNA glycosylase
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TN_cdi_proquest_miscellaneous_19261946
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_19261946
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ISSN
0028-0836
E-ISSN
1476-4687
DOI
10.1038/nature02306
