In vivo Reduction of Amyloid-β by a Mutant Copper Transporter
In vivo Reduction of Amyloid-β by a Mutant Copper Transporter
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Author / Creator
Phinney, Amie L. , Drisaldi, Bettina , Schmidt, Stephen D. , Lugowski, Stan , Coronado, Veronica , Liang, Yan , Horne, Patrick , Yang, Jing , Sekoulidis, Joannis , Coomaraswamy, Janaky , Chishti, M. Azhar , Cox, Diane W. , Mathews, Paul M. , Nixon, Ralph A. , Carlson, George A. , St George-Hyslop, Peter and Westaway, David
Publisher
United States: National Academy of Sciences
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Language
English
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Publisher
United States: National Academy of Sciences
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Scope and Contents
Contents
Cu ions have been suggested to enhance the assembly and pathogenic potential of the Alzheimer's disease$amyloid\!-\!\beta\>(A\beta)$peptide. To explore this relationship in vivo, toxic-milk (txJ) mice with a mutant ATPase7b transporter favoring elevated Cu levels were analyzed in combination with the transgenic (Tg) CRND8 amyloid precursor protein...
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Full title
In vivo Reduction of Amyloid-β by a Mutant Copper Transporter
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Record Identifier
TN_cdi_proquest_miscellaneous_19263341
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_19263341
Other Identifiers
ISSN
0027-8424
E-ISSN
1091-6490
DOI
10.1073/pnas.2332851100
