Opposing effects of cancer-type-specific SPOP mutants on BET protein degradation and sensitivity to...
Opposing effects of cancer-type-specific SPOP mutants on BET protein degradation and sensitivity to BET inhibitors
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Author / Creator
Janouskova, Hana , El Tekle, Geniver , Bellini, Elisa , Udeshi, Namrata D , Rinaldi, Anna , Ulbricht, Anna , Bernasocchi, Tiziano , Civenni, Gianluca , Losa, Marco , Svinkina, Tanya , Bielski, Craig M , Kryukov, Gregory V , Cascione, Luciano , Napoli, Sara , Enchev, Radoslav I , Mutch, David G , Carney, Michael E , Berchuck, Andrew , Winterhoff, Boris J N , Broaddus, Russell R , Schraml, Peter , Moch, Holger , Bertoni, Francesco , Catapano, Carlo V , Peter, Matthias , Carr, Steven A , Garraway, Levi A , Wild, Peter J and Theurillat, Jean-Philippe P
Publisher
New York: Nature Publishing Group US
Journal title
Language
English
Formats
Publication information
Publisher
New York: Nature Publishing Group US
Subjects
More information
Scope and Contents
Contents
Different mutations found in endometrial and prostate tumors affecting the substrate-recognition domain of SPOP, a component of the E3 ubiquitin ligase complex, result in opposing degradation activity of BET proteins and response to BET inhibitors. This work, along with findings by Zhang
et al
. and Dai
et al
., highlights the divergent...
Alternative Titles
Full title
Opposing effects of cancer-type-specific SPOP mutants on BET protein degradation and sensitivity to BET inhibitors
Authors, Artists and Contributors
Author / Creator
El Tekle, Geniver
Bellini, Elisa
Udeshi, Namrata D
Rinaldi, Anna
Ulbricht, Anna
Bernasocchi, Tiziano
Civenni, Gianluca
Losa, Marco
Svinkina, Tanya
Bielski, Craig M
Kryukov, Gregory V
Cascione, Luciano
Napoli, Sara
Enchev, Radoslav I
Mutch, David G
Carney, Michael E
Berchuck, Andrew
Winterhoff, Boris J N
Broaddus, Russell R
Schraml, Peter
Moch, Holger
Bertoni, Francesco
Catapano, Carlo V
Peter, Matthias
Carr, Steven A
Garraway, Levi A
Wild, Peter J
Theurillat, Jean-Philippe P
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_proquest_miscellaneous_1928783202
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_1928783202
Other Identifiers
ISSN
1078-8956
E-ISSN
1546-170X
DOI
10.1038/nm.4372
