Patterns of Nucleotide Misincorporations during Enzymatic Amplification and Direct Large-scale Seque...
Patterns of Nucleotide Misincorporations during Enzymatic Amplification and Direct Large-scale Sequencing of Ancient DNA
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United States: National Academy of Sciences
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Language
English
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United States: National Academy of Sciences
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Contents
Whereas evolutionary inferences derived from present-day DNA sequences are by necessity indirect, ancient DNA sequences provide a direct view of past genetic variants. However, base lesions that accumulate in DNA over time may cause nucleotide misincorporations when ancient DNA sequences are replicated. By repeated amplifications of mitochondrial D...
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Full title
Patterns of Nucleotide Misincorporations during Enzymatic Amplification and Direct Large-scale Sequencing of Ancient DNA
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TN_cdi_proquest_miscellaneous_19327335
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_19327335
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ISSN
0027-8424
E-ISSN
1091-6490
DOI
10.1073/pnas.0605327103
