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Composition and dosage of a multipartite enhancer cluster control developmental expression of Ihh (I...

Composition and dosage of a multipartite enhancer cluster control developmental expression of Ihh (I...

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_1933229359

Composition and dosage of a multipartite enhancer cluster control developmental expression of Ihh (Indian hedgehog)

About this item

Full title

Composition and dosage of a multipartite enhancer cluster control developmental expression of Ihh (Indian hedgehog)

Publisher

New York: Springer New York

Journal title

Nature genetics, 2017-10, Vol.49 (10), p.1539-1545

Language

English

Formats

Publication information

Publisher

New York: Springer New York

More information

Scope and Contents

Contents

Stefan Mundlos, Darío Lupiáñez and colleagues investigate CNVs involving the regulatory landscape of
IHH
(Indian hedgehog), which cause craniosynostosis and synpolydactyly. Using genetic manipulation in mice, they show that
Ihh
is regulated by at least nine enhancers with individual tissue specificities and that duplications in this reg...

Alternative Titles

Full title

Composition and dosage of a multipartite enhancer cluster control developmental expression of Ihh (Indian hedgehog)

Identifiers

Primary Identifiers

Record Identifier

TN_cdi_proquest_miscellaneous_1933229359

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_1933229359

Other Identifiers

ISSN

1061-4036

E-ISSN

1546-1718

DOI

10.1038/ng.3939

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