GFRAL is the receptor for GDF15 and is required for the anti-obesity effects of the ligand
GFRAL is the receptor for GDF15 and is required for the anti-obesity effects of the ligand
About this item
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Author / Creator
Yang, Linda , Chang, Chih-Chuan , Sun, Zhe , Madsen, Dennis , Zhu, Haisun , Padkjær, Søren B , Wu, Xiaoai , Huang, Tao , Hultman, Karin , Paulsen, Sarah J , Wang, Jishu , Bugge, Anne , Frantzen, Jane Boesen , Nørgaard, Per , Jeppesen, Jacob Fuglsbjerg , Yang, Zhiru , Secher, Anna , Chen, Haibin , Li, Xun , John, Linu Mary , Shan, Bing , He, Zhenhua , Gao, Xiang , Su, Jing , Hansen, Kristian T , Yang, Wei and Jørgensen, Sebastian Beck
Publisher
New York: Nature Publishing Group US
Journal title
Language
English
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Publication information
Publisher
New York: Nature Publishing Group US
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Scope and Contents
Contents
GDF15 has potent anti-obesity effects, but its receptor was unknown. GFRAL has now been identified as the receptor that mediates GDF15's effects via central actions in the hindbrain.
Growth differentiation factor 15 (GDF15; also known as MIC-1) is a divergent member of the TGF-β superfamily and is associated with body-weight regulation in humans...
Alternative Titles
Full title
GFRAL is the receptor for GDF15 and is required for the anti-obesity effects of the ligand
Authors, Artists and Contributors
Author / Creator
Chang, Chih-Chuan
Sun, Zhe
Madsen, Dennis
Zhu, Haisun
Padkjær, Søren B
Wu, Xiaoai
Huang, Tao
Hultman, Karin
Paulsen, Sarah J
Wang, Jishu
Bugge, Anne
Frantzen, Jane Boesen
Nørgaard, Per
Jeppesen, Jacob Fuglsbjerg
Yang, Zhiru
Secher, Anna
Chen, Haibin
Li, Xun
John, Linu Mary
Shan, Bing
He, Zhenhua
Gao, Xiang
Su, Jing
Hansen, Kristian T
Yang, Wei
Jørgensen, Sebastian Beck
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_proquest_miscellaneous_1933230829
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_1933230829
Other Identifiers
ISSN
1078-8956,1546-170X
E-ISSN
1546-170X
DOI
10.1038/nm.4394
