GFRAL is the receptor for GDF15 and the ligand promotes weight loss in mice and nonhuman primates
GFRAL is the receptor for GDF15 and the ligand promotes weight loss in mice and nonhuman primates
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New York: Nature Publishing Group US
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English
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New York: Nature Publishing Group US
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GDF15 has potent anti-obesity effects, but its receptor was unknown. GFRAL has now been identified as the receptor and mediates GDF15's effects through central actions in the hindbrain.
Growth differentiation factor 15 (GDF15), a distant member of the transforming growth factor (TGF)-β family, is a secreted protein that circulates as a 25-kDa di...
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GFRAL is the receptor for GDF15 and the ligand promotes weight loss in mice and nonhuman primates
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TN_cdi_proquest_miscellaneous_1933231786
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_1933231786
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1078-8956,1546-170X
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1546-170X
DOI
10.1038/nm.4392
