Fine-tuning PERK signaling to control cell fate under stress
Fine-tuning PERK signaling to control cell fate under stress
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Publisher
New York: Nature Publishing Group US
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Language
English
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Publisher
New York: Nature Publishing Group US
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Contents
PERK is a major sensor of the unfolded protein response controlling cell fate under endoplasmic reticulum (ER) stress. A new study reveals an additional step for optimal PERK signaling, involving the binding of CNPY2 to PERK's luminal domain. The PERK–CNPY2 axis was shown to enhance cell death under ER stress in vivo influence liver disease.
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Full title
Fine-tuning PERK signaling to control cell fate under stress
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TN_cdi_proquest_miscellaneous_1947620608
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_1947620608
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ISSN
1545-9993
E-ISSN
1545-9985
DOI
10.1038/nsmb.3478
