Synthesis and SARs of novel lincomycin derivatives Part 5: optimization of lincomycin analogs exhibi...
Synthesis and SARs of novel lincomycin derivatives Part 5: optimization of lincomycin analogs exhibiting potent antibacterial activities by chemical modification at the 6- and 7-positions
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London: Nature Publishing Group UK
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English
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London: Nature Publishing Group UK
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In order to modify lincomycin at the C-6 and C-7 positions, we prepared target molecules, which have substituted pipecolinic acid at the 6-amino group and a
para
-substituted phenylthio group at the C-7 position, in application of palladium-catalyzed cross-coupling as a key reaction. As the result of structure-activity relationship (SAR) stud...
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Synthesis and SARs of novel lincomycin derivatives Part 5: optimization of lincomycin analogs exhibiting potent antibacterial activities by chemical modification at the 6- and 7-positions
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TN_cdi_proquest_miscellaneous_1958544319
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_1958544319
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ISSN
0021-8820
E-ISSN
1881-1469
DOI
10.1038/ja.2017.114
