Promoter-bound METTL3 maintains myeloid leukaemia by m6A-dependent translation control
Promoter-bound METTL3 maintains myeloid leukaemia by m6A-dependent translation control
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Author / Creator
Barbieri, Isaia , Tzelepis, Konstantinos , Pandolfini, Luca , Shi, Junwei , Millán-Zambrano, Gonzalo , Robson, Samuel C. , Aspris, Demetrios , Migliori, Valentina , Bannister, Andrew J. , Han, Namshik , De Braekeleer, Etienne , Ponstingl, Hannes , Hendrick, Alan , Vakoc, Christopher R. , Vassiliou, George S. and Kouzarides, Tony
Publisher
London: Nature Publishing Group UK
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English
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Publisher
London: Nature Publishing Group UK
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Contents
The methyltransferase METTL3 promotes the leukaemic state in acute myeloid leukaemia (AML) by catalysing the m
6
A RNA modification through its recruitment on the transcription start sites of AML-associated genes.
METTL3 supports tumour growth
N
6
-methyladenosine (m
6
A) is an RNA modification in coding and non-coding RNAs...
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Full title
Promoter-bound METTL3 maintains myeloid leukaemia by m6A-dependent translation control
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TN_cdi_proquest_miscellaneous_1970639269
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_1970639269
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ISSN
0028-0836
E-ISSN
1476-4687
DOI
10.1038/nature24678
