Cellular senescence is an important mechanism of tumor regression upon c-Myc inactivation
Cellular senescence is an important mechanism of tumor regression upon c-Myc inactivation
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United States: National Academy of Sciences
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Language
English
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United States: National Academy of Sciences
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Contents
Oncogene-induced senescence is an important mechanism by which normal cells are restrained from malignant transformation. Here we report that the suppression of the c-Myc (MYC) oncogene induces cellular senescence in diverse tumor types including lymphoma, osteosarcoma, and hepatocellular carcinoma. MYC inactivation was associated with prototypical...
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Full title
Cellular senescence is an important mechanism of tumor regression upon c-Myc inactivation
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TN_cdi_proquest_miscellaneous_19750281
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_19750281
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ISSN
0027-8424
E-ISSN
1091-6490
DOI
10.1073/pnas.0701953104
