Two levels of protection for the B cell genome during somatic hypermutation
Two levels of protection for the B cell genome during somatic hypermutation
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Publisher
London: Nature Publishing Group UK
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Language
English
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Publisher
London: Nature Publishing Group UK
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Hypermutation on a leash
Somatic hypermutation, the mechanism by which activated B cells in the blood produce a diversity of immunoglobulin genes giving rise to high-affinity antibodies, plays a vital role in protecting the body from infection. Yet it also represents a major risk to genomic stability, with the potential to generate B-cell tumour...
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Full title
Two levels of protection for the B cell genome during somatic hypermutation
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TN_cdi_proquest_miscellaneous_19797180
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_19797180
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ISSN
0028-0836
E-ISSN
1476-4687,1476-4679
DOI
10.1038/nature06547
