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Efficient and accurate bypass of N super(2)-(1-carboxyethyl)-2'-deoxyguanosine by DinB DNA polymeras...

Efficient and accurate bypass of N super(2)-(1-carboxyethyl)-2'-deoxyguanosine by DinB DNA polymeras...

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_19805502

Efficient and accurate bypass of N super(2)-(1-carboxyethyl)-2'-deoxyguanosine by DinB DNA polymerase in vitro and in vivo

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Full title

Efficient and accurate bypass of N super(2)-(1-carboxyethyl)-2'-deoxyguanosine by DinB DNA polymerase in vitro and in vivo

Journal title

Proceedings of the National Academy of Sciences - PNAS, 2008-06, Vol.105 (25), p.8679-8684

Language

English

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Subjects and topics

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Scope and Contents

Contents

DinB, a Y-family DNA polymerase, is conserved among all domains of life; however, its endogenous substrates have not been identified. DinB is known to synthesize accurately across a number of N super(2)-dG lesions. Methylglyoxal (MG) is a common byproduct of the ubiquitous glycolysis pathway and induces the formation of N super(2)-(1-carboxyethyl)-...

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Full title

Efficient and accurate bypass of N super(2)-(1-carboxyethyl)-2'-deoxyguanosine by DinB DNA polymerase in vitro and in vivo

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Record Identifier

TN_cdi_proquest_miscellaneous_19805502

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_19805502

Other Identifiers

ISSN

0027-8424

E-ISSN

1091-6490

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