Cooperative targeting of melanoma heterogeneity with an AXL antibody-drug conjugate and BRAF/MEK inh...
Cooperative targeting of melanoma heterogeneity with an AXL antibody-drug conjugate and BRAF/MEK inhibitors
About this item
Full title
Author / Creator
Boshuizen, Julia , Koopman, Louise A , Krijgsman, Oscar , Shahrabi, Aida , van den Heuvel, Elke Gresnigt– , Ligtenberg, Maarten A , Vredevoogd, David W , Kemper, Kristel , Kuilman, Thomas , Song, Ji-Ying , Pencheva, Nora , Mortensen, Jens Thing , Foppen, Marnix Geukes , Rozeman, Elisa A , Blank, Christian U , Janmaat, Maarten L , Satijn, David , Breij, Esther C W , Peeper, Daniel S and Parren, Paul W H I
Publisher
New York: Nature Publishing Group US
Journal title
Language
English
Formats
Publication information
Publisher
New York: Nature Publishing Group US
Subjects
More information
Scope and Contents
Contents
Expression of AXL earmarks melanoma cells resistant to BRAF and MEK inhibitors that either pre-exist in treatment-naive tumors or emerge in response to therapy. The combination of an AXL-MMAE antibody-drug conjugate with BRAF and MEK inhibitors eliminates heterogeneous melanoma cell populations and prolongs survival in experimental
in vivo
mo...
Alternative Titles
Full title
Cooperative targeting of melanoma heterogeneity with an AXL antibody-drug conjugate and BRAF/MEK inhibitors
Authors, Artists and Contributors
Author / Creator
Koopman, Louise A
Krijgsman, Oscar
Shahrabi, Aida
van den Heuvel, Elke Gresnigt–
Ligtenberg, Maarten A
Vredevoogd, David W
Kemper, Kristel
Kuilman, Thomas
Song, Ji-Ying
Pencheva, Nora
Mortensen, Jens Thing
Foppen, Marnix Geukes
Rozeman, Elisa A
Blank, Christian U
Janmaat, Maarten L
Satijn, David
Breij, Esther C W
Peeper, Daniel S
Parren, Paul W H I
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_proquest_miscellaneous_1989590339
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_1989590339
Other Identifiers
ISSN
1078-8956
E-ISSN
1546-170X
DOI
10.1038/nm.4472
