Expression of PFKFB3 and Ki67 in lung adenocarcinomas and targeting PFKFB3 as a therapeutic strategy
Expression of PFKFB3 and Ki67 in lung adenocarcinomas and targeting PFKFB3 as a therapeutic strategy
About this item
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Author / Creator
Li, Xiaoli , Liu, Jian , Qian, Li , Ke, Honggang , Yao, Chan , Tian, Wei , Liu, Yifei and Zhang, Jianguo
Publisher
New York: Springer US
Journal title
Language
English
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Publication information
Publisher
New York: Springer US
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Scope and Contents
Contents
Phosphofructokinase-2/fructose-2, 6-bisphosphatase 3 (PFKFB3) catalyzes the synthesis of F2,6BP, which is an allosteric activator of 6-phosphofructo-1-kinase (PFK-1): the rate-limiting enzyme of glycolysis. During tumorigenesis, PFKFB3 increases glycolysis, angiogenesis, and tumor progression. In this study, our aim was to investigate the significa...
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Full title
Expression of PFKFB3 and Ki67 in lung adenocarcinomas and targeting PFKFB3 as a therapeutic strategy
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Author / Creator
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Record Identifier
TN_cdi_proquest_miscellaneous_1989611306
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_1989611306
Other Identifiers
ISSN
0300-8177
E-ISSN
1573-4919
DOI
10.1007/s11010-017-3258-8
