PARP inhibitors for cancer therapy
PARP inhibitors for cancer therapy
About this item
Full title
Author / Creator
Publisher
Cambridge, UK: Cambridge University Press
Journal title
Language
English
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Publication information
Publisher
Cambridge, UK: Cambridge University Press
Subjects
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Scope and Contents
Contents
Poly(ADP-ribose) polymerase 1 (PARP-1) is a zinc-finger DNA-binding enzyme that is activated by binding to DNA breaks. Poly(ADP-ribosyl)ation of nuclear proteins by PARP-1 converts DNA damage into intracellular signals that activate either DNA repair by the base-excision pathway or cell death. A family of 18 PARPs has been identified, but only the...
Alternative Titles
Full title
PARP inhibitors for cancer therapy
Authors, Artists and Contributors
Author / Creator
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Record Identifier
TN_cdi_proquest_miscellaneous_19922049
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_19922049
Other Identifiers
ISSN
1462-3994
E-ISSN
1462-3994
DOI
10.1017/S146239940500904X
