Exonic Transcription Factor Binding Directs Codon Choice and Affects Protein Evolution
Exonic Transcription Factor Binding Directs Codon Choice and Affects Protein Evolution
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United States: American Association for the Advancement of Science
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Language
English
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Publisher
United States: American Association for the Advancement of Science
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Contents
Genomes contain both a genetic code specifying amino acids and a regulatory code specifying transcription factor (TF) recognition sequences. We used genomic deoxyribonuclease I footprinting to map nucleotide resolution TF occupancy across the human exorne in 81 diverse cell types. We found that -15% of human codons are dual-use codons ("duons") tha...
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Full title
Exonic Transcription Factor Binding Directs Codon Choice and Affects Protein Evolution
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TN_cdi_proquest_miscellaneous_2000358401
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_2000358401
Other Identifiers
ISSN
0036-8075
E-ISSN
1095-9203
DOI
10.1126/science.1243490
