Phase-plate cryo-EM structure of a biased agonist-bound human GLP-1 receptor–Gs complex
Phase-plate cryo-EM structure of a biased agonist-bound human GLP-1 receptor–Gs complex
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Author / Creator
Liang, Yi-Lynn , Khoshouei, Maryam , Glukhova, Alisa , Furness, Sebastian G. B. , Zhao, Peishen , Clydesdale, Lachlan , Koole, Cassandra , Truong, Tin T. , Thal, David M. , Lei, Saifei , Radjainia, Mazdak , Danev, Radostin , Baumeister, Wolfgang , Wang, Ming-Wei , Miller, Laurence J. , Christopoulos, Arthur , Sexton, Patrick M. and Wootten, Denise
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
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Publication information
Publisher
London: Nature Publishing Group UK
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Scope and Contents
Contents
The structure of the glucagon-like peptide 1 receptor (GLP-1R) with its biased agonist exendin-P5 sheds light on both receptor activation and the mechanism of biased agonism.
The basis of bias in class B GPCRs
The glucagon-like peptide 1 receptor (GLP-1R) is a key target for the treatment of type 2 diabetes and obesity. Recently, biased agoni...
Alternative Titles
Full title
Phase-plate cryo-EM structure of a biased agonist-bound human GLP-1 receptor–Gs complex
Authors, Artists and Contributors
Author / Creator
Khoshouei, Maryam
Glukhova, Alisa
Furness, Sebastian G. B.
Zhao, Peishen
Clydesdale, Lachlan
Koole, Cassandra
Truong, Tin T.
Thal, David M.
Lei, Saifei
Radjainia, Mazdak
Danev, Radostin
Baumeister, Wolfgang
Wang, Ming-Wei
Miller, Laurence J.
Christopoulos, Arthur
Sexton, Patrick M.
Wootten, Denise
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Primary Identifiers
Record Identifier
TN_cdi_proquest_miscellaneous_2007426699
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_2007426699
Other Identifiers
ISSN
0028-0836
E-ISSN
1476-4687
DOI
10.1038/nature25773
