A point mutation in the pre-ZRS disrupts sonic hedgehog expression in the limb bud and results in tr...
A point mutation in the pre-ZRS disrupts sonic hedgehog expression in the limb bud and results in triphalangeal thumb–polysyndactyly syndrome
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New York: Nature Publishing Group US
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English
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New York: Nature Publishing Group US
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The zone of polarizing activity regulatory sequence (ZRS) is an enhancer that regulates sonic hedgehog during embryonic limb development. Recently, mutations in a noncoding evolutionary conserved sequence 500 bp upstream of the ZRS, termed the pre-ZRS (pZRS), have been associated with polydactyly in dogs and humans. Here, we report the f...
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Full title
A point mutation in the pre-ZRS disrupts sonic hedgehog expression in the limb bud and results in triphalangeal thumb–polysyndactyly syndrome
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TN_cdi_proquest_miscellaneous_2014139953
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_2014139953
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ISSN
1098-3600
E-ISSN
1530-0366
DOI
10.1038/gim.2018.18
