Crosspresentation by Nonhematopoietic and Direct Presentation by Hematopoietic Cells Induce Central...
Crosspresentation by Nonhematopoietic and Direct Presentation by Hematopoietic Cells Induce Central Tolerance to Myelin Basic Protein
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Publisher
United States: National Academy of Sciences
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Language
English
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Publisher
United States: National Academy of Sciences
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Contents
Central tolerance plays a critical role in eliminating self-reactive T cells specific for peripheral antigens. Here we show that central tolerance of MHC class I-restricted T cells specific for classic myelin basic protein (MBP), a component of the myelin sheath, is mediated by both bone marrow (BM)-derived and nonBM-derived cells. Unexpectedly, BM...
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Full title
Crosspresentation by Nonhematopoietic and Direct Presentation by Hematopoietic Cells Induce Central Tolerance to Myelin Basic Protein
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TN_cdi_proquest_miscellaneous_20211582
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_20211582
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ISSN
0027-8424,1091-6490
E-ISSN
1091-6490
DOI
10.1073/pnas.0804970105
