Improving Viscosity and Stability of a Highly Concentrated Monoclonal Antibody Solution with Concent...
Improving Viscosity and Stability of a Highly Concentrated Monoclonal Antibody Solution with Concentrated Proline
About this item
Full title
Author / Creator
Publisher
New York: Springer US
Journal title
Language
English
Formats
Publication information
Publisher
New York: Springer US
Subjects
More information
Scope and Contents
Contents
Purpose
To explain the effects of the osmolyte proline on the protein-protein interactions (PPI), viscosity and stability of highly concentrated antibody solutions in contrast to other neutral osmolytes.
Methods
The viscosity of ~225 mg/mL mAb solutions was measured with proline, glycine and trehalose as a function of pH and co-solute conc...
Alternative Titles
Full title
Improving Viscosity and Stability of a Highly Concentrated Monoclonal Antibody Solution with Concentrated Proline
Authors, Artists and Contributors
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_proquest_miscellaneous_2033382563
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_2033382563
Other Identifiers
ISSN
0724-8741
E-ISSN
1573-904X
DOI
10.1007/s11095-018-2398-1
