Sonic hedgehog-induced type 3 deiodinase blocks thyroid hormone action enhancing proliferation of no...
Sonic hedgehog-induced type 3 deiodinase blocks thyroid hormone action enhancing proliferation of normal and malignant keratinocytes
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Author / Creator
Dentice, Monica , Luongo, Cristina , Huang, Stephen , Ambrosio, Raffaele , Elefante, Antonia , Mirebeau-Prunier, Delphine , Zavacki, Ann Marie , Fenzi, Gianfranco , Grachtchouk, Marina , Hutchin, Mark , Dlugosz, Andrzej A , Bianco, Antonio C , Missero, Caterina , Larsen, P. Reed and Salvatore, Domenico
Publisher
United States: National Academy of Sciences
Journal title
Language
English
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Publisher
United States: National Academy of Sciences
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Scope and Contents
Contents
The Sonic hedgehog (Shh) pathway plays a critical role in hair follicle physiology and is constitutively active in basal cell carcinomas (BCCs), the most common human malignancy. Type 3 iodothyronine deiodinase (D3), the thyroid hormone-inactivating enzyme, is frequently expressed in proliferating and neoplastic cells, but its role in this context...
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Full title
Sonic hedgehog-induced type 3 deiodinase blocks thyroid hormone action enhancing proliferation of normal and malignant keratinocytes
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Record Identifier
TN_cdi_proquest_miscellaneous_20334674
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_20334674
Other Identifiers
ISSN
0027-8424
E-ISSN
1091-6490
DOI
10.1073/pnas.0706754104
