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RSPO2 inhibition of RNF43 and ZNRF3 governs limb development independently of LGR4/5/6

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RSPO2 inhibition of RNF43 and ZNRF3 governs limb development independently of LGR4/5/6

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_2040763406

RSPO2 inhibition of RNF43 and ZNRF3 governs limb development independently of LGR4/5/6

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London: Nature Publishing Group UK

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Contents

The four R-spondin secreted ligands (RSPO1–RSPO4) act via their cognate LGR4, LGR5 and LGR6 receptors to amplify WNT signalling
1
–
3
. Here we report an allelic series of recessive
RSPO2
mutations in humans that cause tetra-amelia syndrome, which is characterized by lung aplasia and a total absence of the four limbs. Functional s...

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Full title

RSPO2 inhibition of RNF43 and ZNRF3 governs limb development independently of LGR4/5/6

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Record Identifier

TN_cdi_proquest_miscellaneous_2040763406

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_2040763406

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ISSN

0028-0836

E-ISSN

1476-4687

DOI

10.1038/s41586-018-0118-y

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