Protecting neurons from HIV-1 gp120-induced oxidant stress using both localized intracerebral and ge...
Protecting neurons from HIV-1 gp120-induced oxidant stress using both localized intracerebral and generalized intraventricular administration of antioxidant enzymes delivered by SV40-derived vectors
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London: Nature Publishing Group UK
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English
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London: Nature Publishing Group UK
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Human immunodeficiency virus-1 (HIV-1) is the most frequent cause of dementia in adults under 40. We sought to use gene delivery to protect from HIV-1-related neuron loss. Because HIV-1 envelope (Env) gp120 elicits oxidant stress and apoptosis in cultured neurons, we established reproducible parameters of Env-mediated neurotoxicity
in vivo
,...
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Full title
Protecting neurons from HIV-1 gp120-induced oxidant stress using both localized intracerebral and generalized intraventricular administration of antioxidant enzymes delivered by SV40-derived vectors
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TN_cdi_proquest_miscellaneous_20420507
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_20420507
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ISSN
0969-7128
E-ISSN
1476-5462
DOI
10.1038/sj.gt.3303030
