Two Hormones for One Receptor: Evolution, Biochemistry, Actions, and Pathophysiology of LH and hCG
Two Hormones for One Receptor: Evolution, Biochemistry, Actions, and Pathophysiology of LH and hCG
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Publisher
Washington, DC: Endocrine Society
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Language
English
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Publisher
Washington, DC: Endocrine Society
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Abstract
LH and chorionic gonadotropin (CG) are glycoproteins fundamental to sexual development and reproduction. Because they act on the same receptor (LHCGR), the general consensus has been that LH and human CG (hCG) are equivalent. However, separate evolution of LHβ and hCGβ subunits occurred in primates, resulting in two molecules sharing ~8...
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Full title
Two Hormones for One Receptor: Evolution, Biochemistry, Actions, and Pathophysiology of LH and hCG
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TN_cdi_proquest_miscellaneous_2056389882
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_2056389882
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ISSN
0163-769X
E-ISSN
1945-7189
DOI
10.1210/er.2018-00065
