Stability of surface NMDA receptors controls synaptic and behavioral adaptations to amphetamine
Stability of surface NMDA receptors controls synaptic and behavioral adaptations to amphetamine
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New York: Nature Publishing Group US
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Language
English
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New York: Nature Publishing Group US
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Contents
This study shows that chronic amphetamine exposure in rats downregulates the NMDA receptor NR2B subunit on striatal neurons. This loss of NR2B has consequences for synaptic transmission and for behavior, sensitizing the rats to the stimulant.
Plastic changes in glutamatergic synapses that lead to endurance of drug craving and addiction are poorl...
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Full title
Stability of surface NMDA receptors controls synaptic and behavioral adaptations to amphetamine
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TN_cdi_proquest_miscellaneous_20570665
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_20570665
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ISSN
1097-6256
E-ISSN
1546-1726
DOI
10.1038/nn.2300
