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Generation of GTKO Diannan Miniature Pig Expressing Human Complementary Regulator Proteins hCD55 and...

Generation of GTKO Diannan Miniature Pig Expressing Human Complementary Regulator Proteins hCD55 and...

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_2057135295

Generation of GTKO Diannan Miniature Pig Expressing Human Complementary Regulator Proteins hCD55 and hCD59 via T2A Peptide-Based Bicistronic Vectors and SCNT

About this item

Full title

Generation of GTKO Diannan Miniature Pig Expressing Human Complementary Regulator Proteins hCD55 and hCD59 via T2A Peptide-Based Bicistronic Vectors and SCNT

Publisher

New York: Springer US

Journal title

Molecular biotechnology, 2018-08, Vol.60 (8), p.550-562

Language

English

Formats

Publication information

Publisher

New York: Springer US

More information

Scope and Contents

Contents

Pig-to-human organ transplantation has drawn attention in recent years due to the potential use of pigs as an alternative source of human donor organs. While GGTA1 knockout (GTKO) can protect xenografts from hyperacute rejection, complement-dependent cytotoxicity might still contribute to this type of rejection. To prolong the xenograft survival, w...

Alternative Titles

Full title

Generation of GTKO Diannan Miniature Pig Expressing Human Complementary Regulator Proteins hCD55 and hCD59 via T2A Peptide-Based Bicistronic Vectors and SCNT

Identifiers

Primary Identifiers

Record Identifier

TN_cdi_proquest_miscellaneous_2057135295

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_2057135295

Other Identifiers

ISSN

1073-6085

E-ISSN

1559-0305

DOI

10.1007/s12033-018-0091-6

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