Local administration of sarizotan into the subthalamic nucleus attenuates levodopa-induced dyskinesi...
Local administration of sarizotan into the subthalamic nucleus attenuates levodopa-induced dyskinesias in 6-OHDA-lesioned rats
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Berlin/Heidelberg: Springer-Verlag
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Language
English
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Berlin/Heidelberg: Springer-Verlag
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Rationale
Dyskinesia affects the majority of levodopa-treated parkinsonian patients within 5–10 years of treatment with levodopa. Clinical and preclinical observations suggest that an increase in serotoninergic transmission can contribute to the appearance of dyskinesias. It is thus conceivable that a modulation of synaptic dopamine (DA) levels...
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Full title
Local administration of sarizotan into the subthalamic nucleus attenuates levodopa-induced dyskinesias in 6-OHDA-lesioned rats
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TN_cdi_proquest_miscellaneous_20589633
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_20589633
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ISSN
0033-3158
E-ISSN
1432-2072
DOI
10.1007/s00213-008-1452-9
